A visual ERP study of impulse inhibition following a zaleplon-induced nap after sleep deprivation.

A visual ERP study of impulse inhibition following a zaleplon-induced nap after sleep deprivation.

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The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials.Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2) after 30 h of SD; (3) upon sudden awakening, also called 2 h post-drug; (4) 4 h powell and mahoney bloody mary mix post-drug; and (5) 6 h post-drug.Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions.However, no difference was observed between the zaleplon condition and the placebo condition.

In event-related potential (ERP) reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD and sudden awakening in both the zaleplon condition and the placebo condition.These results indicate that SD attenuates resource allocation and error monitoring for NoGo stimuli.In addition, NoGo-P3 latencies were longer in the zaleplon condition compared with the placebo condition at sudden awakening.Additionally, the NoGo-P3 latencies were shorter in the zaleplon condition than in the placebo condition at 4 h and 6 h post-drug.

These results indicate that zaleplon at a dose of 10 mg/day may help subjects achieve a better recovery or iphone 13 price ohio maintain better impulse inhibition function, although the side effects of zaleplon last at least 2 h post-drug.